Microcrystal diffraction, difficult but possible

Membrane proteins and proteomics: love is possible, but so difficult.

Despite decades of extensive research, the large-scale analysis of membrane proteins remains a difficult task. This is due to the fact that membrane proteins require a carefully balanced hydrophilic and lipophilic environment, which optimum varies with different proteins, while most protein chemistry methods work mainly, if not only, in water-based media. Taking this review [Santoni, Molloy and...

Solving difficult structures with electron diffraction

Precession electron diffraction has solved a long-standing challenge in electron diffraction. Further progress promises a general technique for structure determination of difficult crystals.

Protein microcrystal diffraction and the effects of radiation damage with ultra-high-flux synchrotron radiation.

By using ultra-high-flux synchrotron x-radiation from a wiggler source, good Laue diffraction data have been obtained from protein microcrystals of size 30 X 35 X 10 microns3, mounted wet in glass capillaries. At the flux level of 10(13)-10(14) photons per sec/mm2, the radiation damage is still low enough to allow a large survey of reciprocal space for a microcrystal and a complete survey for a...

Three-Dimensional Magnetically-Oriented Microcrystal Array: A Large Sample for Neutron Diffraction Analysis

Primary malignant mixed Müllerian tumour of the fallopian tube: a rare and difficult but possible diagnosis.

To cite: Vale-Fernandes E, Rodrigues F, Serrano P, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-209268 DESCRIPTION Malignant tumours of the fallopian tube are very rare. The most common histological type is highgrade serous adenocarcinoma. Sarcomas occur infrequently and carcinosarcomas or malignant mixed Müllerian tumours (MMMTs) are extremely rar...